‘Certainly, that is certainly about right. I seek for a physical comprehension of Organic programs in the base-up way. I believe you could possibly distinguish three strains of investigate in my group in the intervening time. The main considerations chromosome composition: How can you have a metre-long DNA polymer folded and organised in this type of microscopic mobile? We've designed visualisation procedures that permit us to review how, for instance, SMC proteins loop DNA (video clip on Youtube) so as to Develop up chromosomes.
You regularly get entangled in conversations about science and religion. You may have also prepared many books on the topic. Don’t you feel that at some time We are going to know almost everything and that God’s purpose is going to be more than?
‘It absolutely was simply just a make any difference of finding up a ebook on mobile biology and beginning to go through. I had come from a environment of extremely-large vacuums, cryostats and quantum phenomena, and now I was Doing the job at place temperature with molecular biology kits.
Sculpting nano-electrodes that has a transmission electron beam for electrical and geometrical characterization of nanoparticles.
2010, made a whole new way (‘wedging transfer’) to manipulate nanostructures; very first report of DNA translocation by means of graphene nanopores; and recognized hybrid nanopores by directed insertion of α-hemolysin into strong-condition nanopores
Our research ranges from the biophysics of DNA to artificial cells and beyond. Please take a look down below in the spectrum of our present projects.
Quite a few similar developments adopted, where our team established distinct transistor variants including solitary-electron transistors at area temperature and intramolecular nanotube junctions that acted as rectifying diodes, and coupled a number of transistors into modest evidence-of-theory electronic circuits.
Researching DNA loop extrusion by SMC proteins for chromosome architecture with solitary-molecule assays.
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Bulk-surface coupling identifies the mechanistic connection among Min-protein designs in vivo As well as in vitro
Testing pseudotopological and nontopological types for SMC-pushed DNA loop extrusion against roadblock-traversal experiments
Several new phenomena were learned, https://www.ceesdekker.net and he and his analysis group founded a leading posture In this particular area of investigate. Dekker and his investigation team uncovered new physics of nanotubes as well as explored the feasibility of molecular electronics. In 1998, they ended up the very first to make a transistor determined by a single nanotube molecule.
2005, discovery in the system of DNA uncoiling by topoisomerase enzymes; discovery of extended-vary conformational modifications in Mre11/DNA repair service complexes; and initial pressure measurements on the DNA molecule in a very nanopore
‘I'm pushed by marvel and concerns. On a material degree I come across responses in physics, but I experience my deepest happiness with God. That faith also drives my science And the way I take care of persons.